Yes. Also CO2 and air are completely different gases that react in different ways to pressurization. Most regs can run on both, but they won't work as good on one since they weren't designed for it. Also the CO2 destroys many synthetic materials(i.e. most of your seals) much quicker, which directly affects the quality of your reg.
Retired***2k4 PMI Evo
Currently not playing PBall :(