yah, unless you use a palmers reg, they work well with C02, also if you decide to do this when tuning turn the velocity screw on the gun all the way out and just set the speed with the reg. this will help with efficiency because how the other one on the gun works is just by restricting airflow out of the gun, but you still use the same amount of air each shot, so if you set it with the reg instead of restricting flow you just give it less air so you save gas while accomplishing the same thing.